As a dense yellow fog swirls through the streets of London, a deep melancholy has descended on Sherlock Holmes, who sits in a cocaine-induced haze at 221B Baker Street. His mood is only lifted by a visit from a beautiful but distressed young woman - Mary Morstan, whose father vanished ten years before.

Four years later she began to receive an exquisite gift every year: a large, lustrous pearl. Now she has had an intriguing invitation to meet her unknown benefactor and urges Holmes and Watson to accompany her. And in the ensuing investigation - which involves a wronged woman, a stolen hoard of Indian treasure, a wooden-legged ruffian, a helpful dog and a love affair - even the jaded Holmes is moved to exclaim, 'Isn't it gorgeous!'

Sir Arthur Conan Doyle was born the third of ten siblings on 22 May 1859 in Edinburgh, Scotland. His father, Charles Altamont Doyle, a talented illustrator, was born in England of Irish descent, and his mother, born Mary Foley, was Irish. They were married in 1855.

Although he is now referred to as "Conan Doyle", the origin of this compound surname (if that is how he meant it to be understood) is uncertain. His baptism record in the registry of St Mary's Cathedral in Edinburgh gives 'Arthur Ignatius Conan' as his Christian name, and simply 'Doyle' as his surname. It also names Michael Conan as his godfather.

At the age of nine Conan Doyle was sent to the Roman Catholic Jesuit preparatory school, Hodder Place, Stonyhurst. He then went on to Stonyhurst College, leaving in 1875.

From 1876 to 1881 he studied medicine at the University of Edinburgh. This required that he provide periodic medical assistance in the towns of Aston (now a district of Birmingham) and Sheffield. While studying, Conan Doyle began writing short stories. His first published story appeared in "Chambers's Edinburgh Journal" before he was 20. Following his graduation, he was employed as a ship's doctor on the SS Mayumba during a voyage to the West African coast. He completed his doctorate on the subject of tabes dorsalis in 1885.

In 1885 Conan Doyle married Louisa (or Louise) Hawkins, known as "Touie". She suffered from tuberculosis and died on 4 July 1906. The following year he married Jean Elizabeth Leckie, whom he had first met and fallen in love with in 1897. Due to his sense of loyalty he had maintained a purely platonic relationship with Jean while his first wife was alive. Jean died in London on 27 June 1940.