An Essay on Gleets and An Enquiry into the Nature, Cause, and Cure of a Singular Disease of the Eyes are two seminal medical tracts reprinted together, offering a fascinating glimpse into 18th-century medical thought and practice. The first essay, An Essay on Gleets, delves into the condition known as gleet—a persistent, often chronic discharge from the urethra, typically following gonorrhea. The author meticulously examines the symptoms, underlying causes, and various treatments available at the time, providing detailed case studies and observations. The essay reflects the period's evolving understanding of venereal diseases and their management, highlighting both the limitations and innovations of early modern medicine. The second tract, An Enquiry into the Nature, Cause, and Cure of a Singular Disease of the Eyes, investigates a peculiar and little-understood ocular condition. The author presents a thorough analysis of the disease's symptoms, possible etiologies, and the therapeutic approaches employed to address it. Drawing on clinical experience and contemporary medical literature, the tract offers insights into the diagnostic challenges and experimental treatments characteristic of the era. Together, these works not only document the medical knowledge and practices of their time but also reveal the intellectual curiosity and empirical rigor of early medical writers. This reprint is an invaluable resource for historians of medicine, medical professionals interested in the history of their field, and general readers curious about the evolution of medical science.