A Statement of Facts Tending to Establish an Estimate of the True Value and Present State of Vaccination is a significant historical work authored by Charles Murray in 1807. This book provides a detailed and critical examination of the practice of vaccination, particularly focusing on the smallpox vaccine introduced by Edward Jenner. Murray meticulously compiles and analyzes a wide array of contemporary reports, medical testimonies, and statistical data to assess the efficacy, safety, and public perception of vaccination during its early years of adoption. The author addresses both the successes and the controversies surrounding vaccination, including instances of failure, adverse reactions, and the challenges of widespread implementation. He also explores the social, medical, and ethical implications of vaccination, offering insights into the debates and skepticism that accompanied its introduction. Through careful documentation and reasoned argument, Murray aims to present an objective estimate of vaccination’s true value, advocating for a balanced and evidence-based approach to public health policy. The book serves as an important resource for understanding the early history of vaccination, the development of medical science, and the complexities of public health reform in the early nineteenth century.