The Cleveland Medical Gazette Vol. 1, No. 3, January 1886, is a historical periodical that offers a fascinating glimpse into the medical knowledge, practices, and professional discourse of the late nineteenth century. Published in Cleveland, Ohio, this issue is part of a pioneering series aimed at advancing the medical profession through the dissemination of clinical observations, case studies, and scholarly articles. The January 1886 edition features a diverse array of content, including original research, detailed case reports, reviews of contemporary medical literature, and discussions on public health issues relevant to the era. Readers will find in-depth analyses of diseases, surgical techniques, and therapeutic advancements, as well as editorials reflecting the challenges and ethical considerations faced by physicians of the time. The Gazette also includes correspondence, society proceedings, and news items that provide context to the evolving landscape of American medicine. Rich in historical value, this volume serves as both a resource for medical historians and a testament to the dedication and intellectual curiosity of the medical community in the late 1800s.