An Essay on the Application of the Lunar Caustic in the Cure of Certain Wounds and Ulcers is a pioneering medical treatise authored by John Higginbottom, first published in the early 19th century. This comprehensive work explores the therapeutic use of lunar caustic—chemically known as silver nitrate—in the treatment of various wounds and ulcers. Drawing from his extensive clinical experience, Higginbottom meticulously details the preparation, application, and effects of lunar caustic, advocating for its efficacy in promoting healing, preventing infection, and minimizing scarring. The book is structured as both a practical manual and a scientific argument, offering case studies, observations, and step-by-step instructions for medical practitioners. Higginbottom discusses the historical context of caustic treatments, compares lunar caustic to other remedies, and addresses common misconceptions and objections. He emphasizes the importance of timely intervention, proper wound management, and careful monitoring of patient progress. Throughout the essay, Higginbottom’s writing reflects a commitment to empirical observation and rational analysis, characteristic of the medical advancements of his era. He provides detailed descriptions of various types of wounds and ulcers, including their causes, symptoms, and recommended treatment protocols. The work also includes correspondence with other physicians, further supporting his claims and encouraging the broader adoption of lunar caustic in surgical practice. An Essay on the Application of the Lunar Caustic in the Cure of Certain Wounds and Ulcers stands as a significant contribution to the history of medicine, illustrating the evolution of wound care and the quest for more effective, less invasive treatments. It remains a valuable resource for historians of medicine and those interested in the development of surgical techniques and antiseptic practices.